Residual inflammatory risk at 12 months after acute coronary syndromes is frequent and associated with combined adverse events
نویسندگان
چکیده
Background and aimsResidual inflammatory risk (RIR) after acute coronary syndromes (ACS) may identify patients likely to benefit from anti-inflammatory therapies.MethodsPatients the Special Program University Medicine ACS cohort were divided into four groups according level of hsCRP at baseline 12 months: persistently high RIR, increased RIR (first low, then hsCRP), attenuated high, low or RIR. High was defined as ≥ 2 mg/L. An independently adjudicated incident combined adverse events composite myocardial infarction, clinically indicated revascularization cerebrovascular events.ResultsAmong 1209 with available hsCRP, clinical demographic data, 295 (24.4%) had (delta median (IQR): 2.3 (−9.9; 0.3) (mg/L) 72 (5.96%) +2.45 (1.2; 8.35) (mg/L). A total 390 (32.26%) 3.55 (−10; −2) 452 (37.38%) 0.2 (−0.6; 0.1) Of 90 events, 31 (10.5%) occurred in (multivariable adjusted OR: 1.71, (95% CI 1.08–2.7), p = 0.022) compared three other (increased RIR: 3 (4.2%), 30 (7.7%), 26 (5.8%).ConclusionsPersistently elevated is found a quarter highest events. This underlines need perform intervention trials patients.
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2021
ISSN: ['0021-9150', '1879-1484']
DOI: https://doi.org/10.1016/j.atherosclerosis.2021.01.012